Simultaneous Determination of Metoprolol Succinate and Chlorthalidone by Uv Spectrophotometric Method
نویسندگان
چکیده
A simple and rapid UV spectrophotometric method has been developed for simultaneous estimation of Metoprolol Succinate (MET) and Chlorthalidone (CLT). The absorbances of both drugs were found at 267nm and 243 nm in the range of 12-28 μg/ml (y=0.0024X+0.001; r =0.9996) and 3-7μg/ml (y= -0.0149x+0.0015; r = 0.9991) respectively for MET and CLT in methanol 2 2 solvent system.267 nm and 243 nm were zero crossing point for CLT and MET respectively in first order derivative of UV spectrophotometry. Accuracy and reproducibility of the proposed method was statistically validated by recovery studies. This method is found to be precise and accurate and can easily be employed in the laboratory for the routine estimation of drugs.
منابع مشابه
Absorption Correction Method for Simultaneous Estimation of Metoprolol Succinate and Olmesartan Medoxomil in Combined Tablet Dosage Form
A new, simple, precise, accurate and sensitive UV ‐ Spectrophotometric absorption correction method has been developed for simultaneous determination of Metoprolol Succinate and Olmesartan Medoxomil in combined tablet dosage form. Methanol was used as solvent. Absorbance correction method was based on the property of additivity of absorbances. The two wavelengths on Olmesartan medoxomil curve w...
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